Sofovir-C 400 mg Tablet

৳ 350.00

Generic: Sofosbuvir

Strength: 400 mg

Manufacturer: Beximco Pharmaceuticals Ltd..

Description

Indications

Sofosbuvir is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of chronic hepatitis C (CHC) infection as a component of a combination antiviral treatment regimen.

Sofosbuvir efficacy has been established in subjects with HCV genotype 1, 2, 3 or 4 infection, including those with hepatocellular carcinoma meeting Milan criteria (awaiting liver transplantation) and those with HCV/HIV-1 co-infection.

The following points should be considered when initiating treatment with Sofosbuvir:

  • Monotherapy of Sofosbuvir is not recommended for treatment of CHC.
  • Treatment regimen and duration are dependent on both viral genotype and patient population.
  • Treatment response varies based on baseline host and viral factor.

Dosage & Administration

One 400 mg tablet taken once daily with or without food. Should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC.

Recommended combination therapy: (HCV Mono-infected and HCV/HIV-1 Co-infected)-

  • Genotype 1 or 4: Sofosbuvir + Peginterferon alfa + Ribavirin for 12 weeks
  • Genotype 2: Sofosbuvir + Ribavirin for 12 weeks
  • Genotype 3: Sofosbuvir + Ribavirin for 24 weeks

Sofosbuvir in combination with Ribavirin for 24 weeks can be considered for CHC patients with genotype 1 infection who are Interferon ineligible

Should be used in combination with Ribavirin for treatment of CHC in patients with hepatocellular carcinoma awaiting liver transplantation for up to 48 weeks or until liver transplantation whichever occurs first

A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease

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