Dosage & Administration
Adults: The recommended dosage for mild to moderate infections is 1 gm every 12 hourly. However, dosage may be varied according to the severity of infection, sensitivity of causative organisms and condition of the patient. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. For infections caused by sensitive Pseudomonas spp. daily doses of greater than 6 gm will usually be required
Children: The usual dosage range is 100-150 mg/kg/day in 2 to 4 divided doses. However, in very severe infections doses of up to 200 mg/kg/day may be required.
Neonates: The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses. In severe infections 150-200 mg/kg/day, in divided doses, have been given.
Dosage in gonorrhoea: 500 mg as a single dose.
Respiratory Tract Infections: Acute or chronic bronchitis, bacterial pneumonia, infected bronchiectasis, lung abscess and postoperative chest infections
Urinary Tract Infections: Acute and chronic pyelonephritis, cystitis and asymptomatic bacteriuria
Soft-tissue Infection: Cellulitis, peritonitis and wound
Bone and Joint Infections: Osteomyelitis, septic arthritis
Obstetric and gynaecological infections: Pelvic inflammatory disease Gonorrhoea particularly when penicillin has failed or is unsuitable
Other Bacterial Infections: Meningitis and other sensitive infections suitable for parenteral antibiotic therapy
Septicaema: Septicemia is a serious bloodstream infection. It’s also known as bacteremia, or blood poisoning. Septicemia occurs when a bacterial infection elsewhere in the body, such as in the lungs or skin, enters the bloodstream. This is dangerous because the bacteria and their toxins can be carried through the bloodstream to your entire body.
Prophylaxis: The administration of Cefotaxime prophylactically may reduce the incidence of certain post operative infections in patients undergoing surgical procedures that are classified as contaminated or potentially contaminated or in clean operation where infection would have serious effects.