Dosage & Administration
Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing inhibitory effects of GABA. Other neurotransmitters are not influenced.
Bromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties. It does not possess any antidepressant qualities. Bromazepam shares with other benzodiazepines the risk of abuse, misuse, psychological and/or physical dependence. According to many psychiatric experts Bromazepam has a greater abuse potential than other benzodiazepines because of fast resorption and rapid onset of action.
Use in adult: The optimum dosage and frequency of administration of Bromazepam should be based on the individual patient, the severity of symptoms and previous psychotropic drug history. The usual dosage in general practice is from 3 mg to 18 mg daily in divided doses. In exceptional circumstances, in hospitalized patients, up to the maximum daily dosage of 60 mg, in divided doses, may be given.
Use in elderly: Elderly patients are more sensitive to the actions of Bromazepam. Doses should
not exceed half of those normally recommended
Use in children: Bromazepam is not recommended for paediatric use.
Emotional disturbance: Acute tension and anxiety states. Agitation, insomnia, anxiety and age related depressive reactions.
Functional disturbance in the cardiovascular respiratory system: pseudoangina pectoris, precordial anxiety, tachycardia, emotiogenic hypertension, dyspnea and hyperventilation.
In the gastrointestinal system: Irritable bowel syndrome, epigastric pain, spasm, bloting diarrhoea, etc.
In the genitourinary system: Irritable bladder and dysmenorrhea.
Psychosomatic disorders: psychogenic headache, psychogenic dermatosis, asthma, gastric and duodenal ulcer, ulcerative colitis. Emotional reactions to chronic organic diseases.