Cephradine is used in the treatment of infections caused by sensitive organisms.
- Upper respiratory tract infections: Pharyngitis, sinusitis, otitis media, tonsilitis, laryngotracheobronchitis.
- Lower respiratory tract infections: Acute and chronic bronchitis, lobar, and bronchopneumonia.
- Urinary tract infections: Cystitis, urethritis, pyelonephritis.
- Skin and soft tissue infections: Abscess, cellulitis, furunculosis, impetigo.
- Gastrointestinal tract infections: Bacillary dysentery, enteritis, peritonitis. Bone and joint infection.
- Surgical prophylaxis: It is also used in perioperative prophylactic administration (pre-operatively, intra-operatively, and post-operatively). In the cesarean section, intra-operative (after clamping the umbilical cord) and post-operative use may reduce the incidence of certain postoperative infections
Dosage & Administration
Oral: The usual dose is 1-2 gm daily in 2 to 4 divided doses. In severe and prolonged infection, the dose can be increased up to 4 gm daily which should be taken in equally divided doses.
Injection: The usual dose is 2-4 gm daily which should be given intramuscularly or intravenously in 3-4 divided doses.
Special dose in the following infections:
- Skin and skin structures and respiratory tract infection: Usual dose is 250 mg every 6 hours or 500 mg every 12 hours.
- Lobar pneumonia: 500 mg every 6 hours or 1 gm every 12 hours.
- Urinary tract infection: The usual dose is 500 mg every 12 hours.
- Gastro-intestinal tract infection: 500 mg three to four times daily.
Oral: The usual total dose is 25 to 50 mg/kg/day given in 2 to 4 equally divided doses.
Injection: 50 to 100 mg/kg/day in 4 equally divided doses. The usual total dose may be increased up to 200-300 mg/kg/day.
Perioperative prophylaxis: The recommended dose is 1-2 gm by intramuscular or intravenous route; subsequent parenteral or oral doses are given as appropriate. Therapy should be continued for a minimum of 48-72 hrs. after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained.
Dosage in renal impairment: In patients with impaired renal function, doses and frequency of administration of cephradine must be modified according to the degree of impairment, the severity of infection, the susceptibility of the causative organism, and serum concentration of the drug. For adults, a loading dose of 750 mg should be given subsequently followed by 500 mg with the mentioned time interval:
CrCl >20 ml/min: Time interval 6-12 hours
CrCl 15-19 ml/min: Time interval 12-24 hours
CrCl 10-14 ml/min: Time interval 24-40 hours
CrCl 5-9 ml/min: Time interval 40-50 hours
CrCl <5 ml/min: Time interval 50-70 hours