- Dextromethorphan Hydrobromide 10 mg
- Pseudoephedrine Hydrochloride 30 mg
- Triprolidine Hydrochloride 1.25 mg
Pseudoephedrine is both an α-and β-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of α-adrenergic receptors of the respiratory mucosa. It also directly stimulates β-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.
Triprolidine binds to the histamine H1 receptor. This block the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Dosage & Administration
- Over 12 years: 2 tea-spoon three times daily.
- 6 to 12 years: 1 tea-spoon three times daily.
- 2 to 5 years: 1/2 tea-spoon three times daily.
- 6 months to 2 years: 1/4 tea-spoon three times daily or on advice of a physician only.
Pregnancy & Lactation
Although pseudoephedrine has virtually no blood pressure effect in patients with normal blood pressure, this combination should be used with caution in patients taking antihypertensive agents, tricyclic antidepressants or other sympathomimetic agents such as decongestant, appetite suppressants and amphetamine like psychostimulants. As with other sympathomimetic agents caution should be exercised in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and prostatic enlargement.
This combination should not be used for persistent or chronic cough such as occurs with smoking, asthma, or emphysema or where cough is accompanied by excessive secretions unless directed by a physician.