5-Fluorouracil is indicated alone or in combination for carcinoma of the colon or rectum, carcinoma of the stomach and exocrine pancreas, carcinoma of the liver, carcinoma of the breast (an especially aggressive form of breast cancer), carcinoma of the bladder, carcinoma of the lung, epithelial ovarian carcinoma andcervical carcinoma.
Various protocols exist-
- 500 mg/m2 IV on Days 1-5, OR
- 450-600 mg/m2 IV weekly, OR
- 200-400 mg/m2 IV continuous infusion qD
- Not to exceed 800 mg/day
The commonest schedules being 500 mg/m2 daily for 5 days repeated at 4-weekly intervals.
Intravenous 5-FU can be delivered by rapid intravenous bolus injection or slow infusion. The vial contents can rapidly be injected directly into a peripheral vein. Slow intravenous infusion requires the drug to be diluted in 500 mL of dextrose 5% solution, then infused over 2-3 hours on 5 successive days.
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